By J. Thomale, M. R. Müller, C. Buschfort, S. Seeber, M. F. Rajewsky (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Prof. Doz. Dr. B. Wörmann, Prof. Dr. J. Ritter, Prof. Doz. Dr. U. Creutzig, M. Keating MD PhD, W. Plunkett MD PhD (eds.)
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Additional info for Acute Leukemias VII: Experimental Approaches and Novel Therapies
The exact mechanisms by which these adducts cause cell death and the relative cytotoxic potential of specific lesions are still not known. Enzymatic removal of DNA damage is a key feature of cells to protect their genomic integrety. Our knowledge about the DNA repair machinery of mammalian cell has dramatically increased during recent years and a type of "repair netwok" is emerging with various main routes and a number of subpathways [2,3] (see Fig. 1). The loss of specific functions within this structure has successfully been attributed to the risk of cancer, both in experimental systems and in human epidemiology .
Immunofluorescence staining of 0 6_EtGua in the nuclear DNA of single cells was performed essentially as described . 14 M NaCI, 5 min, O°C). 2 flg/ml in PBS and 1% BSA for 16 h at 4°C, Slides were then washed twice with PBS and stained with goat anti-mouse antibodies (Ig F[ab]2 fragments conjugated with TRITC; 2 flg/ ml PBS/BSA) for 3h at room 5 temperature. The nuclear DNA was counterstained with the fluorescent dye DAPI (3 x 10-7 M in PBS; 10 min). 2). Quantification of Fluorescence Signals in the Nuclear DNA of Individual Cells (lCA).
The observation by Terpstra et al. of a case with leukemia-initiating blasts in SCID-mice from a patient with CD34-/ CD38+ blasts differs from that conclusion. However, analysis of the immunophenotype of this leukemic sample shows that it has to be classified into aberrant acquisition of CD38. According to our results in a large group of patients with newly diagnosed AML, presented in this paper, this group of leukemias is rare and accounts for only 2% of all samples. The function of CD34 has not been fully elucidated (Krause et al.
Acute Leukemias VII: Experimental Approaches and Novel Therapies by J. Thomale, M. R. Müller, C. Buschfort, S. Seeber, M. F. Rajewsky (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Prof. Doz. Dr. B. Wörmann, Prof. Dr. J. Ritter, Prof. Doz. Dr. U. Creutzig, M. Keating MD PhD, W. Plunkett MD PhD (eds.)