By Edgar Collins Bain, Harold W Paxton
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Section 2 describes the IGIPI abstractions for biological processes with application on yeast . Section 3 describes extensions of IGIPI for biomedical information with application on cancer. Section 4 discusses analyzing and reasoning with online information. Section 5 puts in the context of related work. Section 6 concludes the paper. Integration of Genomic, Proteomic and Biomedical Information 2 35 Integrating Biological Process Information: Timegoals The IGIPI framework is based on the concept of timegoals.
A biological process is a network of gene or protein interactions. Integration involves representing the experimental and environmental conditions associated with diﬀerent studies, under which a biological process may be observed. Moreover, genes’ and proteins’ contributions under diﬀerent conditions should be unambiguously represented. Diﬀerent studies and conditions often suggest conﬂicting results on a network of gene or protein interactions, highlighting the non-triviality of integration. The contributions of biological processes to a medical condition, such as cancer, can also be represented with IGIPI.
In BioSem, there are two specific compositional relationships: “Sequential aggregation” and “Segment”. Segment indicates where one entity starts and where it ends in the other entity. For example, in the segment relationship between DNA and Genes, one DNA could have many different genes in different segments. Similarly protein secondary structures and protein domains have a “segment link”. Sequential aggregation refers to the position of one entity within an aggregate entity. For example, a DNA sequence may consist of many nucleic acids.
Alloying elements in steel by Edgar Collins Bain, Harold W Paxton