By D. Scott Linthicum, Nadir R. Farid
Here is an updated assessment of significant new equipment and leads to anti-idiotypes, receptors, and molecular mimicry.It starts off with a dialogue of the theoretical heritage ofthe anti-idiotypic community, it is function within the rules of immune reaction, and the actual features of anti-idiotypic antibodies. It then is going directly to discover many exciting purposes in such parts as insulin motion, thyroid phone functionality, the neurosciences, cardiology, virology, pharmacology, and copy.
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Extra info for Anti-Idiotypes, Receptors, and Molecular Mimicry
Structural correlates of idiotopes. Annu. Rev. immunol. 4:147. 2. , V. Agnello. G. Joslin. J. Winchester. D. Cooper. 32 Robert L. Raison and Allen B. Edmundson 1973. Cross-idiotypic specificity among monoclonal IgM proteins with antigamma-globulin activity. J. Exp. Med. 137:331. 3. J. F. Osserman. 1980. Amyloid related BenceJones proteins bind dinitrophenyl L-Iysine (DNP), p. 351. G. ), Amyloid and amyloidosis. Excerpta Medica, Amsterdam. 4. , F. A. Houghten, S. Fong, R. H. Vaughan, B. A. Carson.
U, ACTH unit. Reproduced with permission from Ref. 4. ACTH binding to rat adrenal glomerulosa cells and similar to those reported by McIlhinney and Schulster (7) for '25I_ACTH binding to whole rat adrenal cells. Thus, by using antibodies directed against a peptide encoded by the complementary RNA for ACTH, we were able to isolate and characterize the ACTH receptor. These studies supported our initial hypothesis that complementary peptides resemble receptor binding sites. Generation of Anti-Endorphin Receptor Antibodies As noted previously, a peptide encoded by the complementary RNA for "'I-endorphin was shown to specifically bind "'I-endorphin (Fig.
McIlhinney. J .. and D. Schulster. 1975. Studies on the binding of "'1labeled corticotropin to isolated rat adrenocortical cells. J. Endocrinol. 64: 175. 8. Carr. L. Bost. E. Blalock. 1986. An antibody to a peptide specified by a RNA that is complementary to "V-endorphin mRNA recognizes an opiate rGceptor. J. Neuroimmunol. 12:329. 9. F .. R. Burke. E. Jacobson. A. Klee. 1985. Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. Proc. Natl. Acad. Sci. USA 82:4974. 10.
Anti-Idiotypes, Receptors, and Molecular Mimicry by D. Scott Linthicum, Nadir R. Farid