Apolipoprotein Mimetics in the Management of Human Disease - download pdf or read online

By G.M. Anantharamaiah, Dennis Goldberg

ISBN-10: 3319173499

ISBN-13: 9783319173498

ISBN-10: 3319173502

ISBN-13: 9783319173504

This entire ebook offers not just the levels within the improvement of this targeted and really good box but in addition updates at the present nation of analysis and improvement of apolipoprotein mimetics as healing modalities for numerous lipid-mediated problems. The e-book involves eleven chapters all written by way of best scientists from well-reputed laboratories within the united states. After an advent through Dr. Godfrey Getz, Professor of medication on the collage of Chicago and the affiliate Editor of the magazine Lipid study, the publication offers a narration of the way a idea may end up in the invention of therapy modalities to a number of devastating illnesses similar to diabetes, Alzheimer’s ailment, arthritis; bronchial asthma; atherosclerosis, persistent rejection of transplanted hearts and cancer.

Present remedies for many of those illnesses should not enough. utilizing the types of 2 lengthy anti-atherogenic and anti inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) brief mimetic peptides of 18 to twenty-eight amino acid residues in size, which might be produced both synthetically or genetically in safe to eat vegatables and fruits, were proven to exert profound organic results in a lot of animal versions of diseases.

The ebook additionally offers novel principles, hugely unforeseen mechanisms of motion in animal versions or even in preliminary scientific experiences in people, which can result in extra advancements in easy and scientific examine in organic technological know-how. the entire chapters are written through specialists of their respective fields who've contributed immensely to the literature. this is often the 1st compendium of this becoming box awarded within the kind of a book.

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Extra resources for Apolipoprotein Mimetics in the Management of Human Disease

Sample text

J Lipid Res 47:832–843 Fazio S, Linton MF (2011) Low levels of high-density lipoprotein cholesterol due to lecithin: cholesterol acyltransferase mutations increase carotid atherosclerosis. J Am Coll Cardiol 58:2488–2490 Forte TM, Nichols AV, Gong EL, Levy RI, Lux S (1971) Electron microscopic study on reassembly of plasma high density apoprotein with various lipids. Biochim Biophys Acta 248:381–386 Glomset JA (1968) The plasma lecithins: cholesterol acyltransferase reaction. J Lipid Res 9:155–167 Gofman JW, Lindgren F (1950) The role of lipids and lipoproteins in atherosclerosis.

J Lipid Res 9:562–569 Castelli WP, Doyle JT, Gordon T, Hames CG, Hjortland MC, Hulley SB, Kagan A, Zukel WJ (1977) HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study. Circulation 55:767–772 Cheung MC, Segrest JP, Albers JJ, Cone JT, Brouillette CG, Chung BH, Kashyap M, Glasscock MA, Anantharamaiah GM (1987) Characterization of high density lipoprotein subspecies: structural studies by single vertical spin ultracentrifugation and immunoaffinity chromatography.

J Lipid Res 47:2148–2160 Buga GM, Frank JS, Mottino GA, Hakhamian A, Narasimha A, Watson AD, Yekta B, Navab M, Reddy ST, Anantharamaiah GM, Fogelman AM (2008) D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet. J Lipid Res 49:192–205 Buga GM, Navab M, Imaizumi S, Reddy ST, Yekta B, Hough G, Chanslor S, Anantharamaiah GM, Fogelman AM (2010) L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation.

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Apolipoprotein Mimetics in the Management of Human Disease by G.M. Anantharamaiah, Dennis Goldberg


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